Protein Misfolding and Aggregation in Ageing and Disease
نویسندگان
چکیده
منابع مشابه
Is Preeclampsia a Protein Misfolding and Aggregation Disease?
Preeclampsia (PE) affects 5-8% of all pregnancies worldwide. It is a pregnancy-specific syndrome characterized by hypertension, proteinuria, edema as well as intrauterine growth restriction. The lack of reliable methods for early diagnosis prior to clinical onset limits the opportunities for prevention and timely treatment of PE. Moreover, there is no efficacious therapy except for delivery. Th...
متن کاملPrinciples of protein folding, misfolding and aggregation.
This review summarises our current understanding of the underlying and universal mechanism by which newly synthesised proteins achieve their biologically functional states. Protein molecules, however, all have a finite tendency either to misfold, or to fail to maintain their correctly folded states, under some circumstances. This article describes some of the consequences of such behaviour, par...
متن کاملProteostasis impairment in protein-misfolding and -aggregation diseases.
Cells possess an extensive network of components to safeguard proteome integrity and maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines in performance, as may be the case during aging, newly synthesized proteins are no longer able to fold efficiently and metastable proteins lose their functionally active conformations, particularly under conditions of cell...
متن کاملα-Synuclein Misfolding and Aggregation in Parkinson’s Disease
Parkinson’s disease (PD) is a fatal neurodegenerative disorder that affects 1.5 millions Americans and 1 in 100 individuals over the age of 60. It results from neuronal atrophy localized within the substantia nigra pars compacta. Upon autopsy, PD patients have large intraneuronal fibrils, Lewy Bodies, composed of αsynuclein. Familial forms of PD result from the A30P and A53T mutations within α-...
متن کاملProtein misfolding, functional amyloid, and human disease.
Peptides or proteins convert under some conditions from their soluble forms into highly ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging from neurodegenerative disorders to systemic amyloidoses. In this review, we identify the diseases known to be associated with formation of fibrillar aggregates and the specific peptides and proteins involved in e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Prion
سال: 2007
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.1.2.4651